Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis.

Benson, Merrill D; Waddington-Cruz, Márcia; Berk, John L; Polydefkis, Michael; Dyck, Peter J; Wang, Annabel K; Planté-Bordeneuve, Violaine; Barroso, Fabio A; Merlini, Giampaolo; Obici, Laura; Scheinberg, Morton; Brannagan, Thomas H; Litchy, William J; Whelan, Carol; Drachman, Brian M; Adams, David; Heitner, Stephen B; Conceição, Isabel; Schmidt, Hartmut H; Vita, Giuseppe; Campistol, Josep M; Gamez, Josep; Gorevic, Peter D; Gane, Edward; Shah, Amil M; Solomon, Scott D; Monia, Brett P; Hughes, Steven G; Kwoh, T Jesse; McEvoy, Bradley W; Jung, Shiangtung W; Baker, Brenda F; Ackermann, Elizabeth J; Gertz, Morie A; Coelho, Teresa.

N Engl J Med ; 379(1): 22-31, 2018 Jul 05.

Artigo em Inglês | MEDLINE | ID: mdl-29972757

2.

SERPINA1 modulates expression of amyloidogenic transthyretin.

Niemietz, Christoph; Bezerra, Filipa; Almeida, Maria Rosário; Guo, Shuling; Monia, Brett P; Saraiva, Maria João; Schütz, Paula; Schmidt, Hartmut H-J; Zibert, Andree.

Exp Cell Res ; 395(2): 112217, 2020 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-32768500

3.

Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy.

Buono, Suzie; Ross, Jacob A; Tasfaout, Hichem; Levy, Yotam; Kretz, Christine; Tayefeh, Leighla; Matson, John; Guo, Shuling; Kessler, Pascal; Monia, Brett P; Bitoun, Marc; Ochala, Julien; Laporte, Jocelyn; Cowling, Belinda S.

Proc Natl Acad Sci U S A ; 115(43): 11066-11071, 2018 10 23.

Artigo em Inglês | MEDLINE | ID: mdl-30291191

4.

In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis.

Bezerra, Filipa; Niemietz, Christoph; Schmidt, Hartmut H J; Zibert, Andree; Guo, Shuling; Monia, Brett P; Gonçalves, Paula; Saraiva, Maria João; Almeida, Maria Rosário.

Int J Mol Sci ; 22(17)2021 Aug 31.

Artigo em Inglês | MEDLINE | ID: mdl-34502397

5.

Antisense Oligonucleotides Targeting Jagged 1 Reduce House Dust Mite-induced Goblet Cell Metaplasia in the Adult Murine Lung.

Carrer, Michele; Crosby, Jeff R; Sun, Guizhen; Zhao, Chenguang; Damle, Sagar S; Kuntz, Steven G; Monia, Brett P; Hart, Christopher E; Grossman, Tamar R.

Am J Respir Cell Mol Biol ; 63(1): 46-56, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32176858

6.

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Kraus, Daniel; Yang, Qin; Kong, Dong; Banks, Alexander S; Zhang, Lin; Rodgers, Joseph T; Pirinen, Eija; Pulinilkunnil, Thomas C; Gong, Fengying; Wang, Ya-chin; Cen, Yana; Sauve, Anthony A; Asara, John M; Peroni, Odile D; Monia, Brett P; Bhanot, Sanjay; Alhonen, Leena; Puigserver, Pere; Kahn, Barbara B.

Nature ; 508(7495): 258-62, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24717514

7.

Steric Inhibition of 5' UTR Regulatory Elements Results in Upregulation of Human CFTR.

Sasaki, Shruti; Sun, Rachel; Bui, Huynh-Hoa; Crosby, Jeff R; Monia, Brett P; Guo, Shuling.

Mol Ther ; 27(10): 1749-1757, 2019 10 02.

Artigo em Inglês | MEDLINE | ID: mdl-31351782

8.

Nonsense-mediated RNA Decay Pathway Inhibition Restores Expression and Function of W1282X CFTR.

Keenan, Melissa M; Huang, Lulu; Jordan, Nikole J; Wong, Eric; Cheng, Yi; Valley, Hillary C; Mahiou, Jerome; Liang, Feng; Bihler, Hermann; Mense, Martin; Guo, Shuling; Monia, Brett P.

Am J Respir Cell Mol Biol ; 61(3): 290-300, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-30836009

9.

Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines.

Holmes-Hampton, Gregory P; Crooks, Daniel R; Haller, Ronald G; Guo, Shuling; Freier, Susan M; Monia, Brett P; Rouault, Tracey A.

Hum Mol Genet ; 25(23): 5178-5187, 2016 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-28007899

10.

Factor XI antisense oligonucleotide for prevention of venous thrombosis.

Büller, Harry R; Bethune, Claudette; Bhanot, Sanjay; Gailani, David; Monia, Brett P; Raskob, Gary E; Segers, Annelise; Verhamme, Peter; Weitz, Jeffrey I.

N Engl J Med ; 372(3): 232-40, 2015 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-25482425

11.

Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide.

Grossman, Tamar R; Carrer, Michele; Shen, Lijiang; Johnson, Robert B; Hettrick, Lisa A; Henry, Scott P; Monia, Brett P; McCaleb, Michael L.

Mol Vis ; 23: 561-571, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28855795

12.

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice.

Arumugam, Paritha I; Mullins, Eric S; Shanmukhappa, Shiva Kumar; Monia, Brett P; Loberg, Anastacia; Shaw, Maureen A; Rizvi, Tilat; Wansapura, Janaka; Degen, Jay L; Malik, Punam.

Blood ; 126(15): 1844-55, 2015 Oct 08.

Artigo em Inglês | MEDLINE | ID: mdl-26286849

13.

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein.

Vu, Trang T; Zhou, Ji; Leslie, Beverly A; Stafford, Alan R; Fredenburgh, James C; Ni, Ran; Qiao, Shengjun; Vaezzadeh, Nima; Jahnen-Dechent, Willi; Monia, Brett P; Gross, Peter L; Weitz, Jeffrey I.

Blood ; 125(17): 2712-9, 2015 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-25691157

14.

Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference.

Povsic, Thomas J; Scott, Rob; Mahaffey, Kenneth W; Blaustein, Robert; Edelberg, Jay M; Lefkowitz, Martin P; Solomon, Scott D; Fox, Jonathan C; Healy, Kevin E; Khakoo, Aarif Y; Losordo, Douglas W; Malik, Fady I; Monia, Brett P; Montgomery, Rusty L; Riesmeyer, Jeffrey; Schwartz, Gregory G; Zelenkofske, Steven L; Wu, Joseph C; Wasserman, Scott M; Roe, Matthew T.

Cardiovasc Drugs Ther ; 31(4): 445-458, 2017 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-28735360

15.

Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits.

Yau, Jonathan W; Liao, Peng; Fredenburgh, James C; Stafford, Alan R; Revenko, Alexey S; Monia, Brett P; Weitz, Jeffrey I.

Blood ; 123(13): 2102-7, 2014 Mar 27.

Artigo em Inglês | MEDLINE | ID: mdl-24501216

16.

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice.

Prakash, Thazha P; Graham, Mark J; Yu, Jinghua; Carty, Rick; Low, Audrey; Chappell, Alfred; Schmidt, Karsten; Zhao, Chenguang; Aghajan, Mariam; Murray, Heather F; Riney, Stan; Booten, Sheri L; Murray, Susan F; Gaus, Hans; Crosby, Jeff; Lima, Walt F; Guo, Shuling; Monia, Brett P; Swayze, Eric E; Seth, Punit P.

Nucleic Acids Res ; 42(13): 8796-807, 2014 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-24992960

17.

Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques.

van Montfoort, Maurits L; Kuijpers, Marijke J E; Knaup, Véronique L; Bhanot, Sanjay; Monia, Brett P; Roelofs, Joris J T H; Heemskerk, Johan W M; Meijers, Joost C M.

Arterioscler Thromb Vasc Biol ; 34(8): 1668-73, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-24947525

18.

Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates.

Crosby, Jeffrey R; Marzec, Ulla; Revenko, Alexey S; Zhao, Chenguang; Gao, Dacao; Matafonov, Anton; Gailani, David; MacLeod, A Robert; Tucker, Erik I; Gruber, Andras; Hanson, Stephen R; Monia, Brett P.

Arterioscler Thromb Vasc Biol ; 33(7): 1670-8, 2013 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-23559626

19.

Antisense therapy for cancer.

Gleave, Martin E; Monia, Brett P.

Nat Rev Cancer ; 5(6): 468-79, 2005 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-15905854

20.

Inhibition of hepatic sulfatase-2 in vivo: a novel strategy to correct diabetic dyslipidemia.

Hassing, H Carlijne; Mooij, Hans; Guo, Shuling; Monia, Brett P; Chen, Keyang; Kulik, Wim; Dallinga-Thie, Geesje M; Nieuwdorp, Max; Stroes, Erik S G; Williams, Kevin Jon.

Hepatology ; 55(6): 1746-53, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-22234891

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